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The chimerical and suicidal nature of polyamines in both cell culture and intact organism: Growth, survival and activity of its natural and synthetic inhibitors. Polyamines have attracted a lot of attention over the past decades as potential antitumor or anticancer drugs. However, it is essential to demonstrate that this group of biologically active compounds is really effective, i.
In this article, we describe the application of a novel approach for the reliable evaluation of the potential acptain of polyamines in vitro and in vivo. We employed this approach to explore the inhibition of the growth of mice fibroblasts by polyamines, to establish the natural origin of polyamines, and to disclose the chimerical and suicidal nature of polyamines.
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